Nampoothiri, S., Esakkidurai, T., Pitchumani, K. (2017). Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study. Trends in Phytochemical Research, 1(4), 227-234.
Suresh Nampoothiri; Thirugnanasamy Esakkidurai; Kasi Pitchumani. "Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study". Trends in Phytochemical Research, 1, 4, 2017, 227-234.
Nampoothiri, S., Esakkidurai, T., Pitchumani, K. (2017). 'Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study', Trends in Phytochemical Research, 1(4), pp. 227-234.
Nampoothiri, S., Esakkidurai, T., Pitchumani, K. Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study. Trends in Phytochemical Research, 2017; 1(4): 227-234.
Evaluation of antidiabetic, anti-inflammatory and LDL oxidation inhibitory potential of Alpinia galanga and Alpinia calcarata -An in vitro study
1Department of Natural Product Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu, India
2Department of Chemistry, Sreekrishna College, Ariyanoor, Guruvayoor, Thrissur, Kerala, India
3Department of Chemistry, Devanga Arts College, Arupukottai, Tamil Nadu, India
Receive Date: 18 August 2017,
Revise Date: 13 October 2017,
Accept Date: 18 October 2017
Abstract
Alpinia galanga and Alpinia calcarata are two important aromatic medicinal plants belong to the family Zingiberaceae. In the present study, dried rhizomes of A. galanga and A. calcarata were extracted with water and then fractionated with different solvents. Among the various solvent fractions, ethyl acetate (EA) fraction of both the plants showed high polyphenolic content with better antioxidant activity. This polyphenol rich EA fraction is also screened for its antidiabetic and anti-inflammatory potential using in vitro assays. Results showed that EA fractions of these two plants had significant antihyperglycemic activity by inhibiting carbohydrate digesting enzymes (α-amylase and α-glucosidase) and by inhibiting glycation reaction. Inhibitory potential of EA fractions of both the plant against protein denaturation and xanthine oxidase validates its anti-inflammatory potential. Moreover, EA fractions also exhibited significant LDL oxidation inhibition .The observed antidiabetic and anti-inflammatory properties of A. galanga and A. calcarata could be due to the synergic effect of polyphenols such as gallic acid and ellagic acid as well as bioactive alkaloid, berberine.
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