Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae)

Document Type: Original Article


1 Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon

2 International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan

3 Department of Chemistry, Higher Teacher Training College, University of Maroua, P.O. Box 55 Maroua, Cameroon

4 Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon

5 Department of Chemistry, Faculty of Science, Scientific and Technical University of Masuku, Box. 943, Franceville, Gabon

6 Department of Chemistry, Karakoram International University, 15100-Gilgit, Gilgit-Baltistan, Pakistan

7 Department of Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon

8 Pharmaceutical Research Centre of Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi 75280, Pakistan

9 Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47 Yaoundé, Cameroon


Ficus vallis-choudae Delile has been reported to exhibit antifungal, anticonvulsant, anti-inflammatory and antinociceptive activities. Herein we report the first ever pharmacochemical studies on the figs of Ficus vallis-choudae resulting in isolation of a new ceramide named nkwenamide (1). Also, seven known compounds including the binary mixture of β-amyrin palmitate (2) and lupeol palmitate (3), olean-12-en-3-one (4), n-hexacosan-1-ol (5), β-sitosterol (6), and mixture of β-amyrin (7) and lupeol (8) were isolated. Their structures were elucidated using spectroscopic methods. The methanol extract of the figs of this plant exhibited urease, and α-glucosidase activities and showed DPPH radical scavenging potency with IC50 values, 61.7, 73.7 and 87.4 µg/mL, respectively. It also showed a weak chemiluminescence activity as compared to ibuprofen. The mixture of 2 and 3 exhibited maximum urease inhibitory activity with IC50 value 23.9 µg/mL while the mixture of 7 and 8 showed the maximum α-glucosidase inhibition with IC50 value 44.0 µg/mL. All the isolates showed weak chemiluminescence activity.

Graphical Abstract

Characterization of bioactive compounds from Ficus vallis-choudae Delile (Moraceae)


Main Subjects

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