Document Type : Original Article


1 Analytical, Structural and Materials Chemistry Laboratory, Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon

2 Department of Chemistry, Faculty of Science, University of Buea, P.O. Box 63, Buea, Cameroon

3 Higher Teachers Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon

4 Head Systems Biology Laboratory CIRCB, of Yaounde I, P.O. Box 3077, Yaounde-Messa, Yaounde, Cameroon



One fatty acid (1), one monoglycol ester (2), three diterpenes (3-5), four steroids (6-9), four triterpenes (10-13), three flavonoids (14-16), three anthraquinones (17-19) and one benzoquinone (20), were isolated from the methanolic extract of the leaves and trunk of Senna alata. These compounds were obtained by extensive silica gel chromatography and their structures elucidated by 1D and 2D nuclear magnetic resonance (NMR) as well as comparison with literature data. Compounds (2-4) have been reported for the first time from this species. Some isolated compounds and methanolic crude extract of leaves and trunk were screened in vitro for their antimicrobial activities. Kaempferol (16) exhibited strong activity against all the tested strains, with MIC values varying from 15.5 to 31.2 µg/mL, emodin (18) was active with a strong activity (7.8 µg/mL) exhibited on Pseudomonas aeruginosa. The trunk crude extract showed a strong activity with MIC values varying from 15.6 to 62.5 µg/mL.

Graphical Abstract

Chemical constituents and antimicrobial activities of some isolated compounds from the Cameroonian species of Senna alata (Cassia alata L. Roxb synonym, The plant list 2013). (Leguminosae)


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