Document Type : Guest editorial


1 Laboratory of Growth Regulators, Institute of Experimental Botany ASCR & Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech Republic

2 Centre for Natural Products Discovery (CNPD), School of Pharmacy and Biomolecular Sciences, John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom



‘Gandho badali’ (Paederia foetida L.), a well-known medicinal plant from the family Rubiaceae with a fetid smell, is indigenous to Bangladesh, but also native to several other South- and Far-Eastern Asian countries like Bhutan, Cambodia, China, India, Indonesia, Japan, Laos, Malaysia, Nepal, South Korea, Taiwan and Vietnam. In addition to the Bengali name ‘Gandho badali’, this perennial climber is also commonly known as ‘Gandhobadulia’, ‘Kings tonic’, ‘Skunkvine’, ‘Stinkvine’ an ‘Chinese fever vine’. Phytochemical investigations on this plant established the presence of alkaloids, anthraquinones, coumarins, iridoids, lignans, phenolics, steroids and terpenoids. Aizarin, asperuloside, campesterol, 1,3-dihydroxy-2-methoxyanthraquinone, digiferrol, ellagic acid, epifriedelinol, friedelin, lupeol, morindaparvin A, paederoside, paederosidic acid, sitosterol, stigmasterol and ursolic acid are the major secondary metabolites found in various parts of P. foetida.


Chauhan, K., Patel, A., Patel, M., Macwan, C., Solankim, R., Adeshara, S., 2010. Paederia foetida Linn. as a potential medicinal plant: A review. J. Pharm. Res.3, 3135-3137.
Chanda, S., Deb, L., Tiwari, R. K., Singh, K., Ahmad, S., 2015. Gastroprotective mechanism of Paederia foetida Linn. (Rubiaceae) – a popular edible plant used by the tribal community of North-East India. BMC Complement. Altern. Med. 15, article number: 304.
Chung, Y.C., 2021. Anti-melanogenic effects of Paederia foetida L. extract via MAPK signaling-mediated MITF downregulations. Cosmetics 8, article number: 22.
Global Invasive Species Database, 2021. Available online at: (accessed on 19 September 2021).
Ha, B-H., Kim, M-W., Lee, J-A., 2021. Study on leaf of Paederia foetida and Paederia scandens for cosmetic materials. J. Korean. Soc. Cosmetol. 11, 121-128.
Li, N., Zhou, H., Chen, X.H., Chen, H., Tang, H.F., Yao, Y.M., 2021. Potential chemopreventive effect of Paederia foetida Linn on benzyo[1]pyrene induced gastric cancer. Lat. Am. J. Pharm. 40, 834-843.
Patel, D.K., 2017. Paederia foetida Linn.: A potential climbing medicinal herb in Central India. IJESNR 6, article number: 555699.
Pradhan, N., Parbin, S., Kausar, C., Kar, S., Mawatwal, S., Das, L., Deb, M., Sengupta, D., Dhiman, R., Patra, S.K., 2021. Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells. Food Chem. Toxicol. 130, 161-173.
Ramadhan, A., Wardani, A.K., Dlamini, D.S., Chang, C.I., 2021. Anthraquinone derivatives and its antibacterial properties from Paederia foetida stems. Nat. Prod. J.11, 193-199.
Soni, R.K., Irchhaiya, R., Dixit, V., Shashi, A., 2013. Paederia foetida Linn: Phytochemistry, pharmacological and traditional uses. Int. J. Pharm. Sci. Res.4, 4525-4530.
Trung, N.Q., Thong, N.M., Cuong, D.M., Manh, T.D., Hoang, L.P., Hien, N.K., Nam, P.C., Quang, D.T., Mechler, A., Vo, Q.V., 2021. Radical scavenging activity of natural anthraquinones: A theoretical insight. ACS Omega 6, 13391-13397.
Wang, L., Jiang, Y., Han, T., Zheng, C., Qin, L., 2014. A phytochemical, pharmacological and clinical profile of Paederia foetida and P. scandens. Nat. Prod. Commun. 9, 879-886.